Edward W. Jernigan, III, MD

Specializing In

Elbow, Hand, Wrist

Dr. Jernigan is a fellowship trained orthopaedic surgeon specializing in conditions affecting the hand, wrist and elbow. His clinical interests include hand, forearm, and elbow fractures and soft tissue trauma including tendon and neurovascular injuries, inflammatory and osteoarthritis, compression neuropathies, wrist disorders, elbow instability, elbow arthroplasty, and management of post amputation neuromas.

Dr. Jernigan began his academic career at the University of North Carolina at Chapel Hill, where he graduated Phi Beta Kappa with highest distinction and received the Department of Chemistry Merck Index Award. He continued at the University of North Carolina at Chapel Hill to receive his medical degree, and during this time he was elected a member of the Alpha Omega Alpha Honor Medical Society. Dr. Jernigan also completed his surgical internship and orthopaedic surgery residency at the University of North Carolina at Chapel Hill.  After residency, Dr. Jernigan completed a fellowship in hand and upper extremity surgery at the Hospital for Special Surgery in New York, ranked by US News and World Report as the #1 orthopaedic hospital.

Dr. Jernigan has authored over 20 peer-reviewed research abstracts, articles, and book chapters on hand, wrist and elbow pathology in some of the top journals in orthopaedic surgery, including the Journal of Hand Surgery and Clinical Orthopaedics and Related Research. He has presented numerous scientific studies at various national orthopaedic conferences. In medical school, he was selected into the Howard Holderness Distinguished Medical Scholars Program, a two year program which included a dedicated basic science research year in an NIH-funded lab. He served as a coordinating council member of the Student Health Action Coalition, a student led organization at UNC providing interdisciplinary service opportunities including medical care at a local, free health clinic.  During residency, Dr. Jernigan was awarded the Resident Research Presentation Award by the North Carolina Orthopaedic Association Hand Breakout Session. He has participated in multiple medical mission trips.

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To schedule an appointment with Dr. Jernigan, please call 919-863-6808.

Medical School
University of North Carolina at Chapel Hill

University of North Carolina at Chapel Hill School of Medicine (General Surgery)

University of North Carolina at Chapel Hill (Orthopaedic Surgery)

Hospital for Special Surgery (Hand & Upper Extremity) in New York City, NY


Raleigh Orthopaedic Clinic: Holly Springs Office

781 Avent Ferry Road #110, Holly Springs, NC 27540


Dedicated to providing specialized bone, joint, and muscle care when you need it, our specialists are available to treat patients full time in Holly Springs. We also offer urgent care hours without an appointment for acute orthopaedic concerns.

*Please note: We are located in the UNC Rex Healthcare of Holly Springs Building.


Clinic Phone: 919-781-5600
Therapy Services Phone: 919-645-1411


Clinic Hours:

Monday – Friday: 8:00 a.m. to 5:00 p.m.

Physical Therapy Hours:

Monday – Thursday: 7:30 a.m. to 6:00 p.m.

Friday: 7:30 to 4:00 p.m.

Clinical Assistant — Erica
919-781-5600 Ext.5207 (voicemail only)

Executive Medical Administrative Assistant — Jamie

Surgery/Test Scheduler — Brenda

Professional Organizations

  • Alpha Omega Alpha Honor Medical Society
  • Howard Holderness Distinguished Medical Scholars Program
  • Eugene S. Mayer Community Service Honor Society
  • Foreign Language and Areas (FLAS) Fellowship
  • John B. Gram Research Society
  • Phi Beta Kappa